DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY A PRACTICAL APPROACH 3ED (HB 2012) Hardcover

The third edition of "Developmental and Reproductive Toxicology" serves as a practical guide to this field within a regulatory context. It has been thoroughly updated to reflect the latest changes and includes entirely new chapters on emerging areas of interest. These new topics cover the testing of biologics (including vaccines), the use of nonhuman primates as preclinical models, developmental immunotoxicity testing, various in vitro assays (like zebrafish, stem cells, and high-throughput screening), in silico systems modeling, evaluating how chemicals harm reproduction, extensive coverage of neurobehavioral testing, and testing under the EU's REACH regulations. Existing chapters on nonclinical juvenile toxicity testing, endocrine disruptor screening, and functional and computational genomics have also been updated. The study of risks from toxicant exposure during prenatal development has broadened to include effects lasting until puberty. There's growing concern about the negative impacts of chemical or physical agents on male and female reproductive processes, and significant progress has been made in understanding the causes and mechanisms of birth defects, as well as the genetic, epigenetic, and environmental factors involved. This book offers current guidance on using and interpreting both the newest and more established research methods in developmental and reproductive toxicology.