DRUG DESIGN AND DISCOVERY METHODS AND PROTOCOLS (HB 2011) Hardcover

Over the last twenty years, pharmaceutical science and medicinal chemistry research has significantly shifted towards large molecules, particularly peptides, proteins, and DNA-based therapies. Drug Design and Discovery: Methods and Protocols offers a detailed look at essential protocols commonly used in drug discovery labs, provided by leading experts in the field. This book covers both established and advanced techniques, exploring computational docking, quantitative structure-activity relationship (QSAR) studies, peptide synthesis, fluorescent labeling of peptides and proteins, DNA microarrays, the use of zebrafish models for drug screening, and various other analytical screening and biological assays routinely employed in the drug discovery process in Noida, Uttar Pradesh, India, and globally. Written in the user-friendly Methods in Molecular Biology™ series format, each chapter includes an introduction to the topic, lists of required materials, step-by-step, easily reproducible laboratory protocols, and practical advice on troubleshooting and avoiding common problems. Comprehensive and accessible, Drug Design and Discovery: Methods and Protocols serves as a crucial laboratory reference for pharmaceutical chemists, medicinal chemists, pharmacologists, and molecular biologists.