Enzyme Kinetics In Drug Metabolism: Fundamentals And Applications (Hb 2014) Hardcover

Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications explores the essential role of drug metabolism and transport in pharmaceutical sciences, emphasizing the practical application of enzyme kinetic principles in understanding drug disposition and elimination. These concepts are widely used to characterize and model the activity of drug-metabolizing enzymes and transporters. Divided into five sections, the book covers fundamental enzyme kinetics, the kinetics of oxidative and conjugative drug-metabolizing enzymes and transporters, various modeling approaches—including innovative systems biology techniques—factors influencing variability such as experimental conditions and pharmacogenomics, and real-world case studies demonstrating these principles in practice. As part of the well-regarded Methods in Molecular Biology series, this book is structured for accessibility, with introductory chapters ideal for beginners, step-by-step experimental protocols, troubleshooting insights, and extensive cross-referencing to enhance learning. Both authoritative and user-friendly, this resource serves as a practical teaching tool for scientists new to enzyme kinetics, particularly those without a strong mathematical background, while also providing valuable support for instructors guiding them through these fundamental concepts.