EPILEPSY MECHANISMS MODELS AND TRANSLATIONAL PERSPECTIVES (PB 2019) Paperback

Despite epilepsy's long history, significant progress in understanding the epileptic brain has only occurred in the last fifty years. Breakthroughs in medication, surgical methods, and innovative treatments like nervous system electrical stimulation have greatly improved outcomes for epilepsy patients. Simultaneously, major advancements in neuroscience have deepened our knowledge of brain structure and function. "Epilepsy: Mechanisms, Models, and Translational Perspectives" integrates recent translational progress, bridging the gap between laboratory discoveries and clinical treatments. Featuring contributions from over 70 leading researchers and clinicians, this comprehensive and up-to-date book offers an overview of the fundamental brain structures and functions involved in seizures, explores new and validated ideas about how epilepsy develops, examines current antiepileptic drug therapies and their molecular targets, reviews the latest in epilepsy surgery and neuroimaging, discusses various non-traditional treatments like the ketogenic diet and vagus nerve stimulation, investigates factors like hormones and behavior that affect seizure risk to personalize treatment strategies, and provides a look into future therapies, including novel drug delivery, gene and stem-cell therapies, and seizure detection methods.