GENOMES 5 5ED (PB 2023) Paperback

"Genomes 5" is a completely updated and revised textbook providing a modern look at genomes and the methods used to study them. Following the structure of previous editions, the book first covers techniques, then the structure of genomes, followed by genome function, and finally genome evolution. It examines the genomes of all types of organisms, from viruses and bacteria to fungi, plants, and animals, including humans and other hominids. The sections on genome sequencing and assembly have been thoroughly updated to include the latest advancements in long-read DNA sequencing. The discussion of genome annotation emphasizes genome-wide RNA mapping, and it covers CRISPR-Cas9 and GWAS methods for determining gene function. The knowledge gained from these techniques forms the basis of chapters describing the three main genome types: eukaryotic, prokaryotic (including eukaryotic organelles), and viral (including mobile genetic elements). The coverage of genome expression and replication takes a truly genomic perspective, focusing on the genome-wide implications of DNA packaging, epigenome modifications, DNA-binding proteins, non-coding RNAs, regulatory genome sequences, and protein-protein interactions. The book also includes examples of how metabolomics and systems biology are applied in genomics. The final chapter explores genome evolution, including the evolution of the epigenome, using genomics to study human evolution, and applying population genomics to improve plant breeding. While established molecular biology methods are included if they remain relevant, the book always explains why a particular method is still important today. "Genomes 5" is the perfect textbook for advanced undergraduate and graduate courses focused on genomes and genomics.