MODERN MECHANOBIOLOGY CONVERGENCE OF BIOMECHANICS DEVELOPMENT AND GENOMICS (HB 2021) Hardcover

Modern mechanobiology brings together the fields of engineering and medicine to advance personalized healthcare. This book builds upon the success of the previous edition, Hemodynamics and Mechanobiology of Endothelium, with a focus on "omic" strategies for studying mechanosignal transduction involved in tissue development, damage, and healing. Contributing chapters from a diverse group of researchers enhance the connection between mechanobiology and precision medicine, aiming to support individualized diagnosis and treatment. The book starts by examining the role of hemodynamic shear stress in vascular diseases and progresses through topics such as cardiovascular development and regeneration, heart valve and cardiac formation, mechanosensitive microRNAs, histone dynamics, computational fluid dynamics, and advanced imaging techniques like light-sheet microscopy. This edition marks a shift from classical biomechanics and signaling toward the use of transgenic models—such as innovative zebrafish and chick embryo systems—making it valuable to readers in academia, industry, and government working within the mechanobiology landscape.