PHARMACEUTICAL BIOCATALYSIS CHEMOENZYMATIC SYNTHESIS OF ACTIVE PHARMACEUTICAL INGREDIENTS (HB 2020) Hardcover

This book explores future directions for industrial biocatalysis, emphasizing environmentally friendly technologies and combined chemical-enzymatic and purely biotechnological methods for creating both established and novel active pharmaceutical ingredients (APIs). It details proven and cutting-edge synthetic pathways using single-step biocatalytic or multi-enzyme reactions. A dedicated chapter discusses how many of these drugs function as enzyme inhibitors, providing diverse examples of targeted enzymes involved in diseases like various cancers, metastatic and infectious diseases, osteoporosis, and cardiovascular problems. The biocatalysts used for API synthesis include a wide range of enzymes such as hydrolases, alcohol dehydrogenases, laccases, imine reductases, reductive aminases, peroxygenases, cytochrome P450 enzymes, polyketide synthases, transaminases, and halogenases, many of which have been enhanced through protein engineering. The book covers the synthesis of various drugs, including alkaloids and antibiotics, non-ribosomal peptides, antimalarial and antidiabetic medications, prenylated xanthones, antioxidants, and numerous crucial (chiral) building blocks needed for pharmaceutical production.